9-Fluorenylmethyl chloroformate

��发布时间：2025-02-28 ��浏览次数：917次

 Chemical Name: 9-Fluorenylmethyl chloroformate

CAS Number: 28920-43-6

Molecular Formula: C14H11ClO2

Molecular Weight: 246.69 g/mol

Appearance: Colorless to pale yellow liquid

Solubility: Soluble in common organic solvents like ether, chloroform, etc., slightly soluble in water

Storage Conditions: Store in a cool, dry place, keep sealed, and avoid exposure to moisture and light.

What is 9-Fluorenylmethyl chloroformate? 9-Fluorenylmethyl chloroformate is an important organic reagent commonly used as a protecting group in synthesis. It is used to protect the amino group of amino acids, peptides, or other molecules, especially in peptide synthesis and organic synthesis processes.

Applications and Uses of 9-Fluorenylmethyl chloroformate:

In Peptide Synthesis: 9-Fluorenylmethyl chloroformate is widely used as a protecting group in peptide synthesis. It effectively protects the amino group of amino acids, preventing unwanted side reactions during synthesis, and is particularly useful for synthesizing complex peptide chains.

In Organic Synthesis: In addition to its use in peptide synthesis, 9-Fluorenylmethyl chloroformate is also employed in various organic chemical reactions, acting as a reagent or intermediate in reactions, particularly with amines to form amide compounds.

In Chemical Reactions: As a protecting group, 9-Fluorenylmethyl chloroformate is commonly used in multi-step organic syntheses, particularly when synthesizing compounds with complex structures, by introducing a protecting group at necessary sites to control reaction selectivity.

In Analytical Chemistry: It is also used as a reagent in chemical analysis, particularly in the detection and separation of amino acids and peptides.

Safety and Side Effects: 

9-Fluorenylmethyl chloroformate is a corrosive chemical that may cause irritation to the skin, eyes, and respiratory system. Direct contact should be avoided, and appropriate protective equipment, including gloves, goggles, and protective clothing, should be worn. The work environment should be well-ventilated.

Summary: 

9-Fluorenylmethyl chloroformate is a widely used protecting group reagent in organic synthesis, particularly in peptide synthesis, chemical synthesis, and chemical analysis. Due to its reactivity, it effectively protects specific chemical groups, helping achieve complex synthesis goals. However, care must be taken during handling, and safety protocols should be followed.