Tianeptine Sodium 30123-17-2

��发布时间：2025-03-27 ��浏览次数：771次

 Chemical Name: Tianeptine Sodium

CAS Number: 30123-17-2

Molecular Formula: C21H25ClN2NaO4S

Molecular Weight: 452.95 g/mol

Appearance: White to off-white crystalline powder

Solubility: Soluble in water, easily soluble in ethanol and dimethyl sulfoxide (DMSO)

Storage Conditions: Store in a cool, dry place, away from direct sunlight, and ensure airtight storage

 

What is Tianeptine Sodium?

Tianeptine Sodium is the sodium salt form of Tianeptine, an antidepressant commonly used to treat depression and its related symptoms. Tianeptine was first discovered by French researchers in the 1980s and has been widely used in clinical practice, particularly for patients who are resistant to traditional antidepressant medications. Chemically, Tianeptine Sodium belongs to the class of tricyclic drugs, but its mechanism of action differs from that of traditional tricyclic antidepressants (such as amitriptyline).

Unlike conventional antidepressants, Tianeptine Sodium does not directly affect the concentrations of serotonin, norepinephrine, or dopamine but instead works by modulating the neuroplasticity of the brain. It is believed to enhance neuronal plasticity, especially in the cortex and hippocampus, thereby improving mood and cognitive function.

 

Mechanisms and Effects of Tianeptine Sodium

Relieves Depressive Symptoms

The primary therapeutic effect of Tianeptine Sodium is its ability to treat depression. It works by modulating the plasticity of the brain's nervous system, improving connections between neurons, and thereby alleviating symptoms of depression. Compared to traditional antidepressants, Tianeptine Sodium's mechanism of action is unique and gentle, effectively reducing symptoms like mood depression and anxiety with fewer side effects.

Improves Cognitive Function

Studies have shown that Tianeptine Sodium has the potential to improve cognitive function, especially in patients with depression, enhancing learning ability and memory. It promotes neuronal growth and repair in the cortex and hippocampus, leading to improvements in cognitive function. This is an important feature distinguishing it from other antidepressants.

Relieves Anxiety

In addition to its antidepressant effects, Tianeptine Sodium also has significant anti-anxiety properties. It can effectively reduce anxiety symptoms caused by mood depression or mental stress, helping alleviate symptoms of anxiety disorders and phobias. Its anti-anxiety effects are generally mild, without causing significant sedation or drowsiness.

Improves Stress Responses

Tianeptine Sodium has a distinct advantage in modulating the neuroplasticity of the nervous system, effectively improving stress responses caused by chronic stress or mood disorders. It helps the brain cope with daily stress and burdens, enhancing overall mood and mental health.

Enhances Brain Neuroplasticity

Tianeptine Sodium promotes neuroplasticity, meaning it strengthens the connections between neurons and increases the adaptability of the nervous system. In this way, it not only alleviates symptoms of depression and anxiety but also has a long-term positive impact on brain health, helping maintain good mental health.

 

Applications of Tianeptine Sodium

Treatment of Depression

Tianeptine Sodium is an effective medication for treating depression, especially for patients who do not respond well to traditional antidepressants (such as SSRIs). As a drug that enhances neuroplasticity, it improves neuronal connections in the brain, effectively alleviating depressive symptoms.

Adjunctive Treatment for Anxiety

Besides treating depression, Tianeptine Sodium is often used to alleviate anxiety symptoms triggered by mood disorders. It regulates the nervous system's function to reduce anxiety, especially in patients with co-occurring emotional disorders.

Improvement of Cognitive and Learning Disorders

Due to its ability to improve cognitive function, Tianeptine Sodium shows potential in treating certain cognitive or learning disorders. It helps enhance learning ability and memory, particularly in patients with depression, where its cognitive improvements are particularly notable.

Mood Regulation and Stress Management

Tianeptine Sodium is helpful for stress management and mood regulation, especially for individuals in long-term stress. It effectively improves mood problems caused by excessive stress, thereby enhancing quality of life.

 

Summary

Tianeptine Sodium is an antidepressant with a unique mechanism, working by enhancing brain neuroplasticity to alleviate symptoms of depression, anxiety, and cognitive disorders. Compared to traditional antidepressants, Tianeptine Sodium has fewer side effects and can improve cognitive function, making it suitable for long-term treatment and brain health improvement. It has wide application potential in the treatment of chronic stress, mood disorders, and cognitive impairments.