2-Bromo-1-Phenyl-1-Butanone

��发布时间：2025-02-27 ��浏览次数：717次

 Chemical Name: 2-Bromo-1-Phenyl-1-Butanone

CAS Number: 1451-83-8

Molecular Formula: C₁₀H₁₁BrO

Molecular Weight: 227.1 g/mol

Appearance: White to pale yellow solid

Solubility: Soluble in organic solvents such as ethanol and acetone; slightly soluble in water

Storage Conditions: Store in a cool, dry place, sealed tightly, and protected from direct sunlight and high temperatures.

What is 2-Bromo-1-Phenyl-1-Butanone?

1-Bromo-1-Phenyl-1-Butanone is an organic chemical compound belonging to the phenylbutanone class. It is commonly used as an intermediate or raw material in organic synthesis, particularly in pharmaceutical synthesis and chemical reactions. The presence of a bromine atom makes it an electrophilic reagent, capable of participating in nucleophilic substitution reactions.

Functions and Applications of 2-Bromo-1-Phenyl-1-Butanone

Intermediate in Organic Synthesis

2-Bromo-1-Phenyl-1-Butanone is widely used in organic synthesis, especially in the production of pharmaceuticals and other chemical compounds. As a key reaction intermediate, it participates in various organic reactions, including nucleophilic substitution and addition reactions.

Pharmaceutical Synthesis

This compound serves as a precursor for certain pharmaceuticals, particularly in the synthesis of psychoactive substances, analgesics, and related drug classes. Due to the presence of the bromine atom in its structure, it can react with other chemical compounds to form biologically active molecules.

Electrophilic Reagent in Chemical Reactions

The presence of the bromine atom gives 2-Bromo-1-Phenyl-1-Butanone strong electrophilic properties, making it highly reactive in nucleophilic substitution reactions. This characteristic enhances its utility in various synthetic reactions requiring electrophilic activation.

Research Applications

This compound is also used in chemical research for studying organic reaction mechanisms and optimizing synthetic methods. As a model molecule, it helps researchers explore new reaction pathways and improve existing synthetic routes.

Safety and Side Effects

2-Bromo-1-Phenyl-1-Butanone is generally safe for use in chemical synthesis; however, direct contact with skin and eyes should be avoided. As a brominated compound, it may cause irritation, necessitating the use of appropriate personal protective equipment, such as gloves and safety goggles, during handling. In case of accidental ingestion or inhalation, immediate medical attention is advised.

Conclusion

2-Bromo-1-Phenyl-1-Butanone is an important organic synthesis intermediate widely used in pharmaceutical synthesis and other organic chemical reactions. Its bromine-containing structure grants it strong electrophilic properties, making it a valuable reagent in synthetic chemistry. For chemists involved in organic synthesis, it is a useful tool compound, but proper safety precautions should be taken to ensure safe handling.