9-Methyl-β-carboline

��发布时间：2025-02-26 ��浏览次数：683次

Chemical Name: 9-Methyl-9H-pyrido[3,4-b]indole
Molecular Formula: C₁₂H₁₀N₂
Molecular Weight: 182.22 g/mol
Appearance: White to light yellow crystalline powder
Melting Point: 105.0 - 109.0°C
Solubility: Soluble in organic solvents such as chloroform, dichloromethane, ethyl acetate, dimethyl sulfoxide (DMSO), and acetone.

Overview:

9-Methyl-β-carboline is a β-carboline derivative with a unique chemical structure, widely used in pharmaceutical research, as well as in the pesticide and dye industries, serving as a raw material and intermediate.

Main Functions:

Neuroprotective Effects: Studies have shown that 9-Methyl-β-carboline exhibits neuroprotective properties by stimulating the growth of dopaminergic neurons, increasing the expression of nerve growth factors, and enhancing mitochondrial respiratory chain activity. In animal models of Parkinson's disease, it has been found to restore dopamine levels and neuron count.
Cognitive Function Improvement: Research in rodents has demonstrated that 9-Methyl-β-carboline can elevate dopamine levels in the hippocampus, enhance spatial learning ability, and promote dendrite and synapse proliferation.
Monoamine Oxidase Inhibitor: 9-Methyl-β-carboline has been identified as an inhibitor of monoamine oxidase A and B, making it a potential candidate for research in neurodegenerative diseases.

Application Fields:

Due to its neuroprotective and cognitive-enhancing properties, 9-Methyl-β-carboline is used as a research tool in neuroscience, exploring its potential therapeutic applications in neurodegenerative diseases such as Parkinson's disease.

Safety and Precautions:

When handling 9-Methyl-β-carboline, laboratory safety protocols should be followed to avoid direct skin and eye contact. As it remains primarily a research compound with limited clinical application, it should be used cautiously under professional supervision.