Rapamycin CAS 53123-88-9

��发布时间：2025-03-27 ��浏览次数：923次

 Chemical Name: Rapamycin

CAS Number: 53123-88-9

Molecular Formula: C51H79NO13

Molecular Weight: 914.2 g/mol

Appearance: White to pale yellow crystalline powder

Solubility: Slightly soluble in water, soluble in organic solvents (such as ethanol, dimethyl sulfoxide, etc.)

Storage Conditions: Store in a cool, dry place, protected from direct sunlight.

What is Rapamycin?
Rapamycin is a natural antibiotic originally isolated from a bacterium called Streptomyces hygroscopicus found in soil. Initially used to treat certain types of fungal infections, it was later discovered to have potent immunosuppressive and anticancer properties. Rapamycin is widely used in organ transplant patients to prevent rejection and has significant applications in cancer treatment and aging research.

Mechanisms and Applications of Rapamycin

Immunosuppressive Effects
Rapamycin inhibits the activity of mTOR (mammalian target of rapamycin), regulating cell proliferation and metabolism while suppressing immune system activity. It is widely used in organ transplantation to prevent organ rejection and help maintain the long-term survival of transplanted organs.

Anticancer Effects
Due to its ability to inhibit cell proliferation and induce apoptosis, Rapamycin has important applications in cancer research. By inhibiting the mTOR pathway, it interferes with the growth of tumor cells and has been used in the treatment of certain cancers, such as kidney cancer and breast cancer.

Anti-Aging Potential
Recent studies have found that Rapamycin may combat the aging process by delaying cellular senescence and improving cellular function. It has been shown to extend lifespan in experimental animals, making it a hot topic in aging research. Rapamycin is considered a potential drug in anti-aging studies.

Cardiovascular Health
Rapamycin is also used in cardiovascular disease research. It can reduce the occurrence of atherosclerosis by regulating the proliferation and migration of vascular smooth muscle cells. For heart transplant patients, it helps improve long-term outcomes post-transplantation.

Neuroprotective Effects
Due to its regulatory effects on the mTOR pathway, Rapamycin's potential in neurodegenerative diseases is gradually being recognized. Studies suggest that Rapamycin can promote neuroprotective mechanisms in the brain, potentially aiding in the treatment of diseases such as Alzheimer's and Parkinson's.

Safety and Side Effects
Although Rapamycin has broad applications in many fields, it may cause certain side effects, especially with long-term use. Common side effects include mouth ulcers, high blood sugar, liver function impairment, and immune system suppression. The use of this drug requires medical supervision to ensure proper dosage and treatment safety.

Summary
Rapamycin is a drug with multiple functions, including immunosuppression, anticancer, and anti-aging effects. It is widely used in organ transplantation, cancer treatment, and aging research. Despite its significant medical value, potential side effects, particularly its immunosuppressive effects, must be carefully considered. Therefore, patient health must be closely monitored during treatment.