Baclofen CAS 1134-47-0

��发布时间：2025-03-27 ��浏览次数：813次

 Chemical Name: 4-Amino-3-(4-chlorophenyl)butanoic acid

Molecular Formula: C10H12ClNO2

Molecular Weight: 213.66 g/mol

Appearance: White or off-white crystalline powder

Melting Point: Approximately 252.5°C

Solubility: Slightly soluble in water, soluble in methanol

Introduction:

Baclofen is a derivative of gamma-aminobutyric acid (GABA), primarily used to treat muscle spasms caused by spinal cord injuries, multiple sclerosis, and other conditions. It works by activating GABA_B receptors to inhibit nerve conduction, resulting in muscle relaxation.

Main Actions:

Muscle Relaxation: Baclofen activates GABA_B receptors, inhibiting monosynaptic and polysynaptic reflexes in the spinal cord, which reduces muscle spasms and stiffness.

Analgesic Effects: Baclofen can reduce pain associated with muscle spasms by inhibiting the release of the neurotransmitter substance P.

Anxiolytic Effects: Baclofen has a sedative effect, which can help alleviate symptoms of nervous tension and anxiety.

Precautions:

Common side effects of Baclofen include drowsiness, dizziness, and weakness. Long-term use, especially abrupt discontinuation, can cause serious reactions such as seizures and rhabdomyolysis. Therefore, the dosage should be gradually reduced when stopping the medication.

The safety of Baclofen during pregnancy is not well-established, and it is recommended to use it under medical supervision. It may be safe for use during breastfeeding, but oral administration should be avoided.

Summary:

Baclofen is a muscle relaxant widely used to treat muscle spasms caused by neurological conditions. It should be used according to medical guidance, with attention to possible side effects and withdrawal reactions.