Sodium Deoxycholate

��发布时间：2025-03-05 ��浏览次数：1000次

 Chemical Name: Sodium Deoxycholate

CAS Number: 302-95-4

Molecular Formula: C24H39NaO4

Molecular Weight: 414.56 g/mol

Appearance: White to off-white crystalline powder

Solubility: Soluble in water, ethanol, and acetone

Storage Conditions: Store in a dry, cool place, avoiding moisture and direct sunlight

 

What is Sodium Deoxycholate?

Sodium Deoxycholate is a naturally occurring bile salt widely used in biomedical and chemical research. It is the sodium salt form of deoxycholic acid, a bile acid derived from cholesterol metabolism, commonly found in the bile of mammals. Due to its strong surfactant properties, Sodium Deoxycholate is used as a surfactant, emulsifier, and solubilizing agent in various applications.

As a surfactant, Sodium Deoxycholate disrupts cell membranes, affecting cellular functions. It is commonly used as a cell lysing agent and plays a key role in cell disruption, solubilization, and protein extraction experiments.

 

Functions and Benefits of Sodium Deoxycholate

1. Surfactant and Emulsifier

Sodium Deoxycholate is an effective surfactant widely used in chemical and biological experiments. It can alter the surface tension between water and oil, facilitating the mixing of immiscible substances. As an emulsifier, it is frequently utilized in drug delivery systems to disperse lipid-soluble drugs uniformly in aqueous solutions, enhancing their solubility.

2. Cell Lysis and Protein Extraction

In biological research, Sodium Deoxycholate is commonly used for cell lysis experiments. It disrupts the phospholipid bilayer of cell membranes, allowing the release of intracellular components. This enables researchers to extract and isolate proteins, nucleic acids, and other cellular components for further biochemical analysis.

3. Enhancing Drug Permeability

Due to its surfactant properties, Sodium Deoxycholate is used as a drug penetration enhancer, improving drug absorption across biological membranes. This is particularly valuable in transdermal drug delivery and gastrointestinal absorption studies, making it beneficial in pharmaceutical formulations aimed at increasing drug bioavailability.

4. Liposomal Formulation Aid

Sodium Deoxycholate is frequently used in the preparation of liposomes—small lipid-based particles that encapsulate drugs to enhance stability and bioavailability. Liposomes are widely utilized in drug delivery systems for targeted drug release, particularly in cancer treatment applications.

5. Applications in Cell Culture and Research

In cell culture and gene transfection experiments, Sodium Deoxycholate is often used to permeabilize cell membranes, facilitating intracellular delivery of substances or gene transfection. It is also used in bioreactors and large-scale cell culture systems to promote efficient cell growth.

 

Applications of Sodium Deoxycholate

1. Biological and Medical Research

Sodium Deoxycholate is extensively used in biological and medical research for cell lysis, protein extraction, and nucleic acid isolation. It effectively disrupts cell membranes, releasing intracellular contents for subsequent biochemical analysis.

2. Drug Delivery and Permeability Studies

Due to its ability to enhance drug permeability, Sodium Deoxycholate plays a crucial role in pharmaceutical development. It is commonly incorporated into drug delivery systems to improve drug absorption and bioavailability, particularly in topical and transdermal formulations.

3. Emulsifier in Cosmetics and Personal Care Products

As an emulsifier, Sodium Deoxycholate is used in cosmetic formulations to improve the stability of emulsions. It helps blend oil and water phases, forming stable emulsions widely used in skincare, cosmetics, and personal care products.

4. Clinical Applications

In medical treatments, Sodium Deoxycholate is sometimes used as part of bile acid therapy, particularly for cholesterol gallstone treatment. By modulating bile acid composition, it may help dissolve gallstones or prevent their formation.

 

Conclusion

Sodium Deoxycholate is a highly effective surfactant widely applied in biological research, drug delivery systems, cell lysis, and cosmetic formulations. Its ability to enhance drug permeability, facilitate liposome formation, and assist in protein extraction makes it an essential component in medical and chemical research. With its diverse applications in medicine and industry, Sodium Deoxycholate remains an indispensable tool in scientific and pharmaceutical development.