2-Hydroxypropyl-β-Cyclodextrin (HP-β-CD)

��发布时间：2025-03-05 ��浏览次数：718次

 Chemical Name: 2-Hydroxypropyl-β-Cyclodextrin (HP-β-CD)

CAS Number: 128446-35-5

Molecular Formula: C21H42O11

Molecular Weight: 474.57 g/mol

Appearance: White to off-white crystalline or powder

Solubility: Highly soluble in water

Melting Point: Approximately 200°C (decomposes)

Storage Conditions: Store in a cool, dry place, away from direct sunlight and high temperatures

 

What is 2-Hydroxypropyl-β-Cyclodextrin (HP-β-CD)?

2-Hydroxypropyl-β-Cyclodextrin (HP-β-CD) is a modified cyclodextrin derivative obtained by introducing hydroxypropyl groups (-CH2CHOHCH3) onto the β-cyclodextrin molecule. Cyclodextrins are composed of seven glucose units linked by α-1,4-glycosidic bonds, forming a cyclic structure that enables the encapsulation of other molecules to form inclusion complexes. The introduction of hydroxypropyl groups enhances the water solubility, encapsulation ability, and stability of HP-β-CD, making it widely used in drug delivery, food, cosmetics, and other fields.

Due to its structural properties, HP-β-CD can form inclusion complexes with various drug molecules, flavors, or active ingredients, thereby improving their solubility, stability, and bioavailability. As one of the most widely used cyclodextrin derivatives, HP-β-CD plays an important role in pharmaceuticals, food additives, and industrial applications.

 

Functions and Benefits of 2-Hydroxypropyl-β-Cyclodextrin (HP-β-CD)

1. Drug Delivery and Solubility Enhancement

HP-β-CD is widely used in drug delivery systems, particularly for poorly soluble drugs that are difficult to absorb. It forms inclusion complexes with drugs, significantly increasing their solubility and bioavailability, thereby enhancing therapeutic efficacy.

By encapsulating drug molecules, HP-β-CD helps prevent their degradation in the gastrointestinal tract, improving drug stability and enabling controlled release.

HP-β-CD is especially beneficial for formulations of poorly soluble drugs, providing a more stable and effective delivery method.

2. Improving Food Taste and Stability

HP-β-CD is used as a food additive to encapsulate flavors, colorants, and nutritional components, ensuring their stability in food products and preventing their volatilization or oxidation during processing and storage.

Its inclusion properties enhance the taste of certain food components, improving overall food quality and flavor.

3. Applications in Cosmetics

In the cosmetics industry, HP-β-CD is used to enhance the solubility and stability of active ingredients. It can encapsulate skincare ingredients such as vitamins and plant extracts, improving their absorption into the skin and enhancing their effectiveness.

HP-β-CD also helps control the release of volatile ingredients in skincare products, prolonging their effects and making the products more effective.

4. Formulation Improvement for Poorly Soluble Drugs

Many drugs have low solubility, resulting in poor absorption and low bioavailability. HP-β-CD can form inclusion complexes with these drugs, significantly increasing their solubility and improving their absorption in the body.

This makes HP-β-CD a key component in the formulation of anticancer, antiviral, and antibacterial drugs, where enhanced solubility can lead to improved therapeutic outcomes.

5. Environmental and Industrial Applications

In environmental protection, HP-β-CD can adsorb and remove environmental pollutants such as harmful organic compounds and heavy metal ions from water. Its inclusion properties enable it to bind with pollutants, reducing their environmental impact.

In industrial applications, HP-β-CD is used for separation and purification processes, helping to extract or remove specific components from complex mixtures.

Application Areas of 2-Hydroxypropyl-β-Cyclodextrin (HP-β-CD)

1. Pharmaceutical Industry

Due to its excellent encapsulation capabilities, HP-β-CD is widely used in drug delivery, particularly in improving the solubility and bioavailability of poorly soluble drugs.

It is employed in the development of various drug formulations, including oral solutions, injections, and solid dosage forms.

2. Food Industry

HP-β-CD is used as a food additive to improve the stability and solubility of flavors, colorants, and nutritional components, enhancing taste and extending shelf life.

It is also used to encapsulate fat-soluble ingredients, ensuring their uniform distribution and stability in aqueous food systems.

3. Cosmetic Industry

In cosmetics, HP-β-CD is used to encapsulate active ingredients, improving their stability and skin absorption, making cosmetic products more effective and long-lasting.

It also enhances the stability and controlled release of fragrances and essential oils, improving overall product performance.

4. Environmental Protection and Industrial Applications

In environmental and industrial applications, HP-β-CD is used for pollutant adsorption and removal, contributing to environmental purification.

 

Conclusion

2-Hydroxypropyl-β-Cyclodextrin (HP-β-CD) is widely applied in drug delivery, food, cosmetics, and environmental protection due to its excellent encapsulation properties and high water solubility. It not only improves the stability and bioavailability of drugs and food ingredients but also enhances the performance and efficacy of various products. With ongoing scientific research, HP-β-CD holds great promise for future applications in innovative products and technologies.