Palmitoylethanolamide (PEA) 544-31-0

��发布时间：2025-03-04 ��浏览次数：887次

 Chemical Name: Palmitoylethanolamide

CAS Number: 544-31-0

Molecular Formula: C18H37NO2

Molecular Weight: 341.5 g/mol

Appearance: White crystalline powder

Solubility: Slightly soluble in water, soluble in organic solvents like ethanol and acetone

Storage Conditions: Store in a cool, dry place, avoiding moisture and high temperatures

 

What is Palmitoylethanolamide (PEA)?

Palmitoylethanolamide (PEA) is a naturally occurring fatty acid amide that belongs to the class of endocannabinoid derivatives. It is widely present in various plants, animals, and the human body. It is synthesized from palmitic acid and ethanolamine, usually through endogenous pathways, and is involved in regulating various physiological functions. PEA exerts its anti-inflammatory, analgesic, and neuroprotective effects primarily by interacting with receptors in the body, such as CB2 and TRPV1.

 

Functions and Applications of Palmitoylethanolamide (PEA)

Pain and Inflammation Relief
PEA, as a natural analgesic, is effective in alleviating various types of pain, especially chronic pain and neuropathic pain. It reduces the release of inflammatory mediators by regulating inflammation in the nervous system, thus helping to alleviate pain caused by inflammation. PEA is also believed to modulate the activity of pain neurons by interacting with receptors in the body, helping to reduce pain caused by nerve damage.

Neuroprotective Effects
PEA plays a crucial role in the nervous system and has neuroprotective functions. It helps maintain neuronal health by reducing oxidative stress and inflammation in neurons. In neurodegenerative diseases, PEA has the potential to promote neural repair and slow the progression of neural damage, making it an important subject of research in conditions like Parkinson's disease and Alzheimer's disease.

Anti-Anxiety and Antidepressant Effects
PEA has been found to regulate neurotransmitters in the brain, such as serotonin (5-HT) and GABA (gamma-aminobutyric acid), exerting anti-anxiety and antidepressant effects. It helps improve mood and psychological well-being, contributing to the relief of anxiety and depressive symptoms induced by stress. Due to its good safety profile and minimal side effects, PEA is used as an adjunct in some anti-anxiety and antidepressant treatments.

Anti-Allergy Effects
Research shows that PEA has anti-allergic properties. It helps reduce allergic reactions by inhibiting the release of mediators from mast cells. PEA has shown positive effects in the treatment of allergic diseases, such as allergic rhinitis and asthma.

Improvement of Sleep Quality
PEA can also improve sleep quality through its sedative effects. By interacting with the TRPV1 receptor, it helps relax the nervous system, alleviating sleep problems caused by anxiety or pain.

Alleviating Pain from Chronic Diseases
For those experiencing long-term pain due to chronic conditions like arthritis or neuropathy from diabetes, PEA offers an effective relief method. It can regulate inflammation and pain perception, improving the quality of life for patients and alleviating discomfort caused by chronic diseases.

Antioxidant Properties
PEA also has antioxidant effects, helping to neutralize free radicals in the body and reduce oxidative stress that damages cells and tissues. This property gives PEA potential in the anti-aging and antioxidant health fields.

 

Applications

Chronic Pain Management
PEA is widely used as a supplement for the relief of chronic pain, especially pain caused by inflammation or nerve damage. It is commonly used as an adjunct therapy for conditions like rheumatoid arthritis, sciatica, and fibromyalgia.

Neuroprotection
As a neuroprotective agent, PEA is extensively researched for its potential in the treatment of neurodegenerative diseases. It shows promise in treating conditions such as Parkinson’s disease and Alzheimer’s disease, and is becoming a popular area of study.

Mental Health
As a natural anti-anxiety and antidepressant compound, PEA is added to some mental health products to help alleviate anxiety, depression, and other emotional issues, particularly in modern life where stress and mental strain are high.

Anti-Allergy Medication
Due to its anti-allergy properties, PEA is used as an adjunct treatment for allergic diseases, such as allergic rhinitis and asthma.

Health Supplements
PEA is widely used in health supplements to support joint health, neurological health, immune function, and more, due to its multiple health benefits.

 

Safety and Side Effects

PEA is considered safe and has minimal side effects. Most people do not experience any significant discomfort when using PEA at reasonable doses. Occasionally, some users may experience mild gastrointestinal discomfort, especially with high doses. Overall, PEA is a well-tolerated supplement with low side effects.

 

Conclusion

Palmitoylethanolamide (PEA) is a natural fatty acid amide with multiple effects, including anti-inflammatory, analgesic, neuroprotective, and anti-anxiety properties. It is widely used in chronic pain management, neuroprotection, mental health, and other areas. As a safe and natural supplement, PEA is becoming an important ingredient in pain management and neurodegenerative disease treatments.