Nicotinamide 98-92-0

��发布时间：2025-03-03 ��浏览次数：431次

 Chemical Name: Nicotinamide

CAS Number: 98-92-0

Molecular Formula: C6H6N2O

Molecular Weight: 122.12 g/mol

Appearance: White crystalline or crystalline powder

Solubility: Easily soluble in water, ethanol, and ether

Storage Conditions: Store in a cool, dry, sealed container, avoiding direct sunlight and high temperatures

What is Nicotinamide?

Nicotinamide is a form of vitamin B3, widely found in foods, especially in animal liver, meats, nuts, and legumes. It is a precursor to the coenzyme NAD (Nicotinamide adenine dinucleotide) and plays an important role in maintaining cell health and energy metabolism by participating in various biochemical reactions in the body. Nicotinamide is commonly used as a dietary supplement and as a skincare ingredient.

Roles and Applications of Nicotinamide

Skin Health
Nicotinamide is widely used as an active ingredient in skincare products due to its anti-inflammatory, antioxidant, and skin barrier-repairing properties. Studies show that nicotinamide can reduce sebum production, help treat acne, lighten skin pigmentation, and alleviate redness and inflammation. It also enhances skin barrier function, improves skin hydration, and reduces water loss.

Improving Energy Metabolism
As a precursor to NAD+, Nicotinamide participates in energy metabolism within the body, helping maintain normal cell function. NAD+ is an important coenzyme in cells, involved in various metabolic reactions, especially playing a critical role in ATP (cellular energy) production. Supplementing with nicotinamide can help improve cellular energy supply, supporting normal physiological activities in the body.

Enhancing DNA Repair
Nicotinamide helps boost DNA repair mechanisms, reducing DNA damage caused by oxidative stress. By regulating NAD+ levels, it promotes the activity of PARP (Poly (ADP-ribose) polymerase), thereby enhancing the cell's ability to repair DNA damage. This makes nicotinamide potentially useful for anti-aging and protecting cells from damage.

Neuroprotective Effects
Nicotinamide has protective effects on the brain. By increasing NAD+ levels, it helps provide energy to neurons and supports their repair. Research has shown that nicotinamide may have neuroprotective effects in studies of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, potentially helping delay disease progression.

Promoting Blood Sugar Control
Nicotinamide is also related to blood sugar control. Studies have found that it supports insulin secretion and the function of pancreatic beta cells. Although more research is needed for verification, there is evidence that nicotinamide may play a role in managing diabetes and metabolic syndrome.

Treating Skin Diseases and Inflammation
Nicotinamide is used to treat various skin conditions, including psoriasis, eczema, skin redness, and skin allergies. Its anti-inflammatory properties can help alleviate symptoms such as redness, swelling, and pain caused by these conditions.

Preventing and Treating Oral Diseases
Nicotinamide is also used in some oral care products, particularly to help reduce the occurrence of gingivitis and mouth ulcers. It helps repair oral mucosa and enhances immune response within the mouth.

Side Effects and Safety of Nicotinamide

Nicotinamide is generally safe and does not cause significant side effects when used at recommended doses. Excessive intake as a supplement may lead to mild side effects, such as skin redness, itching, or headaches. Due to its widespread use in skincare products, it is typically considered non-irritating and suitable for most skin types. However, individuals with sensitive skin may experience allergic reactions, so it is best to perform a patch test before use.

Summary

Nicotinamide, as an important nutrient and active ingredient, is widely applied in fields such as skincare, energy metabolism, DNA repair, and neuroprotection. It plays a significant role in improving skin health, enhancing cell repair, boosting energy levels, and anti-aging. Whether used in skincare products or as a dietary supplement, nicotinamide serves as an effective component for daily health maintenance and treatment.