L-5-Methyltetrahydrofolate Calcium

��发布时间：2025-03-03 ��浏览次数：359次

 Chemical Name: L-5-Methyltetrahydrofolate calcium

CAS Number: 151533-22-1

Molecular Formula: C20H23CaN7O6

Molecular Weight: 507.60 g/mol

Appearance: White to off-white crystalline powder

Solubility: Soluble in water

Storage Conditions: Should be stored in a cool, dry place, avoiding direct sunlight and high-temperature environments

 

What is L-5-Methyltetrahydrofolate Calcium ?

L-5-Methyltetrahydrofolate calcium is the active form of folate, a folate derivative. It is the primary metabolic form of folate in the body and is usually stabilized and made more bioavailable by adding a calcium salt. Folate is a member of the B vitamin family, involved in one-carbon metabolism in the body, and is essential for cell division, DNA synthesis, and repair. L-5-Methyltetrahydrofolate, as a bioavailable form, can be directly utilized by the body without undergoing complex conversion processes.

L-5-Methyltetrahydrofolate calcium is commonly used to supplement folate deficiency, particularly in individuals who cannot efficiently convert folate, such as those with genetic mutations (e.g., MTHFR mutation). The calcium salt form helps enhance stability, making it more effective in drugs and supplements.

 

Functions and Benefits of L-5-Methyltetrahydrofolate Calcium

Folate Supplementation and Prevention of Deficiency

L-5-Methyltetrahydrofolate calcium directly serves as the active form of folate, effectively supplementing folate in individuals who are deficient. Folate is crucial for pregnant women in early stages of pregnancy, as it plays a vital role in the development of the fetal nervous system and helps prevent neural tube defects.

It also helps improve anemia caused by folate deficiency, promoting the production of red blood cells and reducing the occurrence of macrocytic anemia.

Improves DNA Synthesis and Cell Repair

L-5-Methyltetrahydrofolate participates in cellular DNA synthesis and repair, which is vital for cell division and proliferation. This makes it important for promoting normal cell growth, especially for rapidly dividing cells such as blood and skin cells.

Furthermore, L-5-Methyltetrahydrofolate also plays a crucial role in one-carbon unit transfer in the body, which aids in homocysteine metabolism, contributing to cardiovascular health.

Supports Cardiovascular Health

By promoting the conversion of homocysteine, L-5-Methyltetrahydrofolate helps lower homocysteine levels in the body. Studies show that elevated homocysteine is a risk factor for cardiovascular diseases, and L-5-Methyltetrahydrofolate can help reduce the risk of heart disease by improving this metabolic process.

It can enhance vascular health, support cardiovascular function, and reduce the likelihood of cardiovascular disease.

Improves Brain Function and Cognitive Health

The active form of folate, L-5-Methyltetrahydrofolate, also plays a critical role in brain health. It participates in the synthesis of neurotransmitters and directly influences mood and cognitive function.

Research suggests that folate helps reduce the incidence of depression and anxiety, and may have a positive effect on the prevention of dementia and cognitive decline, especially in elderly populations.

Enhances Immune Function

L-5-Methyltetrahydrofolate also helps maintain normal immune function. It plays a role in the proliferation and maturation of immune cells, especially white blood cells and T cells.

Folate deficiency often leads to weakened immune function and increased susceptibility to infections, but L-5-Methyltetrahydrofolate can help strengthen the body's immune defense.

Supports Maternal Health

Folate is an essential nutrient for pregnant women, particularly in the early stages of pregnancy, as it can effectively prevent fetal neural tube defects such as spina bifida and anencephaly. L-5-Methyltetrahydrofolate, as the active form of folate, improves the utilization of folate in pregnant women, thereby more effectively supporting healthy fetal development.

 

Applications of L-5-Methyltetrahydrofolate Calcium

Pharmaceuticals and Supplements

L-5-Methyltetrahydrofolate calcium is commonly used in folate supplements, particularly for pregnant women, the elderly, and those with folate conversion disorders (e.g., MTHFR gene mutations).

It is widely used in treating anemia, preventing fetal neural tube defects, and raising folate levels in the body.

Food and Nutritional Supplements

L-5-Methyltetrahydrofolate calcium is also used as a functional food additive, added to nutritional supplements and fortified foods to help improve folate intake, especially for individuals who have difficulty obtaining sufficient folate from their diet.

Women's Health and Prenatal Nutrition

Due to its important role in preventing fetal neural tube defects, L-5-Methyltetrahydrofolate calcium is commonly included as part of prenatal vitamins to support the health of both the mother and fetus.

 

Summary

L-5-Methyltetrahydrofolate calcium  is an active form of folate that plays a crucial role in the body. It effectively improves folate deficiency, preventing neural tube defects, anemia, and other health issues, and also plays an important role in DNA synthesis, cell repair, and cardiovascular health. Particularly for pregnant women and the elderly, supplementation with L-5-Methyltetrahydrofolate calcium offers significant benefits. As our understanding of the biological functions of folate deepens, L-5-Methyltetrahydrofolate calcium holds broad prospects for applications in medicine and nutrition.